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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX3X All Species: 22.73
Human Site: S620 Identified Species: 35.71
UniProt: O00571 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00571 NP_001347.3 662 73243 S620 F S S S R A S S S R S G G G G
Chimpanzee Pan troglodytes Q6GVM6 660 73172 S618 F G A S R G S S S R S G G G G
Rhesus Macaque Macaca mulatta XP_001095294 910 100218 S869 S F S S S R A S S S R S G G G
Dog Lupus familis XP_861268 662 73195 S620 F S S S R A G S S R S G G G G
Cat Felis silvestris
Mouse Mus musculus Q62167 662 73083 S620 F S S S R A S S S R S G G G G
Rat Rattus norvegicus NP_001102328 659 72976 N617 F S S G R A S N S R S G G G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512924 651 71975 S606 F S S S R A S S S R S S G G G
Chicken Gallus gallus NP_001025971 651 72031 R609 S S S F S S S R P A S G R T G
Frog Xenopus laevis P24346 697 77284 S655 A G S S F G S S R G G R S S G
Zebra Danio Brachydanio rerio NP_571016 688 75828 R646 G G G G F G G R G G R S T G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VHP0 798 85063 S739 R S G P P P R S G G S G S G G
Honey Bee Apis mellifera XP_391829 701 78642 G660 S G S A R N N G S S N R P G S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M2F9 646 69224 G584 G G G G G Y G G V P G G G Y G
Baker's Yeast Sacchar. cerevisiae P24784 617 67899 G576 R D Y R K H G G N G S F G S T
Red Bread Mold Neurospora crassa Q9P6U9 688 72037 G632 G F G G G F G G A P A S G G Y
Conservation
Percent
Protein Identity: 100 91.3 70.1 99.8 N.A. 98.6 95.3 N.A. 95.9 91.2 82.2 76.3 N.A. 51.7 58 N.A. N.A.
Protein Similarity: 100 95.3 70.3 99.8 N.A. 99 97.1 N.A. 97.2 94.7 88 83.8 N.A. 63.4 70 N.A. N.A.
P-Site Identity: 100 80 46.6 93.3 N.A. 100 80 N.A. 93.3 40 33.3 13.3 N.A. 40 26.6 N.A. N.A.
P-Site Similarity: 100 86.6 53.3 93.3 N.A. 100 86.6 N.A. 93.3 46.6 33.3 13.3 N.A. 40 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 49.5 49.4 52
Protein Similarity: N.A. N.A. N.A. 64.6 65.2 64.8
P-Site Identity: N.A. N.A. N.A. 20 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. 20 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 7 0 34 7 0 7 7 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 40 14 0 7 14 7 0 0 0 0 0 7 0 0 0 % F
% Gly: 20 34 27 27 14 20 34 27 14 27 14 54 67 74 74 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 7 7 7 7 0 7 0 0 0 0 % N
% Pro: 0 0 0 7 7 7 0 0 7 14 0 0 7 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 14 0 0 7 47 7 7 14 7 40 14 14 7 0 0 % R
% Ser: 20 47 60 47 14 7 47 54 54 14 60 27 14 14 14 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 7 7 7 % T
% Val: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 7 0 0 0 0 0 0 0 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _